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Erinn’s OTEIM guides, pediatric photobiomodulation research and transcranial safety literature.

Research, with context

Photobiomodulation (PBM) uses light to influence biological processes. Transcranial PBM applies light over the head. Pediatric evidence remains limited; small, short-term studies do not establish long-term safety or effectiveness in children. Adult and laboratory findings cannot be assumed to apply to a developing brain.

These articles are educational, not home-treatment instructions or an endorsement of a device. Discuss suitability, eye protection, device-specific precautions and any adverse effects with a qualified clinician. Do not copy research settings into a child’s plan.

Pediatric oral supportive-care studies address mouth sores during cancer treatment. They are a separate evidence base and do not establish the safety or effectiveness of light applied over a child’s head.

22 articles

Getting started

The ABCs of Pediatric Occupational Therapy

Understand what pediatric OT is and how it supports meaningful everyday activities.

Erinn Askin · OTEIM

Open article
Everyday life

Building Independence

Explore OTEIM’s guide to approaching daily tasks and developing independence.

Erinn Askin · OTEIM

Open article
Learning & attention

Boost Focus

Learn about attention, organization and executive-function skills from OTEIM.

Erinn Askin · OTEIM

Open article
Connection & communication

Empowering Communication

Read about communication and family involvement in OTEIM’s speech therapy guide.

Erinn Askin · OTEIM

Open article
Getting started

Early Intervention & Therapeutic Preschool

Understand early support, preschool participation and the family’s role.

Erinn Askin · OTEIM

Open article
PBM & children

Transcranial photobiomodulation in children aged 2–6 years: a randomized sham-controlled clinical trial assessing safety, efficacy, and impact on autism spectrum disorder symptoms and brain electrophysiology

2024 · Randomized sham-controlled trial · Children ages 2–6 with autism

A small randomized study of 30 children with autism compared active transcranial PBM with sham treatment and examined clinical scores and brain electrophysiology.

Fradkin Y, De Taboada L, Naeser M, et al. · Frontiers in Neurology

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PBM & children

Transcranial photobiomodulation for reducing symptoms of autism spectrum disorder and modulating brain electrophysiology in children aged 2–7: an open label study

2025 · Open-label study · Children ages 2–7 with autism

An uncontrolled study of 23 children with autism examined changes in clinical scores and brain electrophysiology after transcranial PBM.

Fradkin Y, Anguera JA, Simon AJ, et al. · Frontiers in Child and Adolescent Psychiatry

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PBM & children

Transcranial Photobiomodulation for the Treatment of Children with Autism Spectrum Disorder (ASD): A Retrospective Study

2022 · Retrospective study · Children with autism

A retrospective report describing transcranial PBM in children with autism; an early observational contribution to the pediatric literature.

Pallanti S, Di Ponzio M, Grassi E, Vannini G, Cauli G · Children

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PBM & children

Transcranial Photobiomodulation for Spasticity in Pediatric Cerebral Palsy: A Scoping Review of Neurodevelopmental Considerations, Treatment Protocols, Functional Outcomes, and Methodological Gaps

2026 · Scoping review · Pediatric cerebral palsy literature

A 2026 scoping review examining the small pediatric cerebral palsy evidence base, developing-brain considerations and gaps in safety reporting.

Jiménez A, Carrick FR, Jemni M · Brain Sciences

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PBM & children

Transcranial photobiomodulation for neurodevelopmental disorders: a narrative review

2024 · Narrative review · Preclinical and clinical literature

A review of preclinical and clinical PBM evidence related to autism, ADHD and Down syndrome.

Coelho DRA, Renet C, López-Rodríguez S, Cassano P, Vieira WF · Photochemical & Photobiological Sciences

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PBM & children

Efficacy of Laser Acupuncture for Children With Autism Spectrum Disorder: Clinical, Molecular, and Biochemical Study

2023 · Randomized comparison · laser acupuncture · Children with autism

Related pediatric light-therapy research examining laser acupuncture in children with autism—not transcranial PBM.

Elsheikh MS, Ashaat EA, Ramadan A, et al. · Pediatric Neurology

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Transcranial PBM safety

Tolerability and Safety of Transcranial Photobiomodulation for Mood and Anxiety Disorders

2022 · Clinical safety analysis · Adults with mood/anxiety disorders

Adult clinical safety and tolerability evidence for transcranial PBM in mood and anxiety disorders.

Cassano P, Norton R, Caldieraro MA, et al. · Photonics

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Transcranial PBM safety

Dose-dependent tolerability and safety of transcranial photobiomodulation: a randomized controlled trial

2025 · Randomized trial · secondary safety analysis · Adults with major depressive disorder

A secondary safety analysis of a sham-controlled trial in 31 adults with major depressive disorder, comparing tolerability across different study doses.

Coelho DRA, Vieira WF, Hurtado Puerto AM, et al. · Lasers in Medical Science

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Transcranial PBM safety

Transcranial photobiomodulation for brain diseases: review of animal and human studies including mechanisms and emerging trends

2024 · Research review · Animal and human literature

A broad review of transcranial PBM mechanisms and animal and human research, useful for understanding the field’s evidence and uncertainties.

Lin HR, Li D, Zhu J, et al. · Neurophotonics

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Transcranial PBM safety

Shining light on the head: Photobiomodulation for brain disorders

2016 · Narrative review · Preclinical and clinical brain-disorder literature

A foundational review of proposed mechanisms and early animal and clinical research into brain-directed PBM.

Hamblin MR · BBA Clinical

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Transcranial PBM safety

Brain Photobiomodulation Therapy: A Narrative Review

2018 · Narrative review · Preclinical and clinical neurological literature

A review of proposed mechanisms and preclinical and clinical evidence across neurological and psychological conditions.

Salehpour F, Mahmoudi J, Kamari F, Sadigh-Eteghad S, Rasta SH, Hamblin MR · Molecular Neurobiology

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Transcranial PBM safety

Penetration Profiles of Visible and Near-Infrared Lasers and Light-Emitting Diode Light Through the Head Tissues in Animal and Human Species: A Review of Literature

2019 · Literature review · tissue penetration · Animal and human head-tissue studies

A review of how light travels through animal and human head tissues, including variability between species and measurement methods.

Salehpour F, Cassano P, Rouhi N, et al. · Photobiomodulation, Photomedicine, and Laser Surgery

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Pediatric oral supportive care

Low-level laser therapy for oral mucositis in children with cancer

2021 · Systematic review & meta-analysis · Children and young people with cancer

A systematic review of light-based treatment for painful oral mucositis in children and young people receiving cancer care.

Redman MG, Harris K, Phillips B · Archives of Disease in Childhood

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Pediatric oral supportive care

Photobiomodulation for oral mucositis management in pediatric patients: a systematic review

2024 · Systematic review · Pediatric patients with oral mucositis

A review of 20 studies examining PBM for oral mucositis in pediatric patients, including prevention and management evidence.

Calarga CC, Cotomácio CC, Simões A · Lasers in Medical Science

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Pediatric oral supportive care

A systematic review and meta-analysis of the effect of low-level laser therapy (LLLT) on chemotherapy-induced oral mucositis in pediatric and young patients

2018 · Systematic review & meta-analysis · Pediatric and young patients receiving chemotherapy

A pediatric-focused evidence synthesis on light-based supportive care for chemotherapy-related oral mucositis.

He M, Zhang B, Shen N, Wu NQ, Sun J · European Journal of Pediatrics

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Pediatric oral supportive care

Low-level laser or LED photobiomodulation on oral mucositis in pediatric patients under high doses of methotrexate: prospective, randomized, controlled trial

2021 · Prospective randomized controlled trial · Pediatric patients receiving high-dose methotrexate

A prospective randomized study comparing laser and LED approaches for oral mucositis in a defined pediatric cancer-care setting.

Guimarães DM, Ota TMN, da Silva DAC, et al. · Supportive Care in Cancer

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Pediatric oral supportive care

An exploration of the use of photobiomodulation for management of oral mucositis in children and young people undergoing cancer treatment in the UK

2022 · Mixed-methods practice survey · UK pediatric oncology centers

A survey of UK pediatric oncology centers describing PBM use and practical barriers to oral mucositis supportive care.

Heggie C, Gray-Burrows KA, Day PF, Phillips B · Supportive Care in Cancer

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